Cell therapy tries to replace damaged or absent cells in a patient’s body with new, healthy cells through stem cells. Obtaining sufficient cells for transplantation into a patient is a difficult task in this type of therapy. This is true because specialized cells from the human body, such as brain cells, are harvested. Furthermore, because specialized cells have a limited growth capacity, it is difficult to obtain adequate cells for specific cell therapy applications.
Cell Therapy Research and Development
Stem cells are unspecialized cells that can differentiate into a wide range of different types of functional cells in the body. The ability to generate stem cells outside of the human body is particularly significant since it allows for the generation of huge cells for cell therapy applications to be developed.
Kinds of Stem Cells in Cell Therapy
Pluripotent stem cells
Pluripotent stem cells can generate every kind of cell in the human body. Consequently, pluripotent stem cells may serve as a source of otherwise unavailable cells, or they may be discovered in tiny numbers in human bodies. They can also be kept and reproduced outside of the human body for extended periods.
Two types of pluripotent stem cells
- Embryonic stem cells are derived from early embryos.
- Induced pluripotent stem cells are derived through a process known as reprogramming.
Tissue-specific ( adult) stem cells
Tissue-specific stem cells have a far narrower functional cell type repertoire than pluripotent stem cells, which may give rise to any human cell type. Blood stem cells, for example, give birth to other blood cells but seldom produce cells outside the circulation.
Pluripotent or tissue-specific stem cells are grown in a lab and treated with a cocktail of chemicals that signal their development into functional cells to produce specialized cells. Check this biotechnology company to learn more about cell therapy manufacturing.
The advancement of cell therapy manufacturing is transforming the nature of health care. Cell therapies have been used successfully for many years. Bone marrow transplantation is the oldest example, often used in medicine to treat particular blood and immune system diseases such as leukemia, lymphoma, and myeloma.
The bone marrow transplant contains blood stem cells, which may replenish the blood and immune system after transferring to the recipient. This kind of stem cell therapy has shown that cell therapies may be used to treat patients. It’s becoming increasingly common to utilize stem cells from the eye to heal eye ailments. KBI biophysical characterization has the expertise and tools to help speed cell therapy development.
It is critical to have well-established ways for generating the appropriate cell types required for cellular therapies to succeed. It’s also vital to ensure that the transplanted cells survive and integrate into the patient’s body so that they can carry out their functions as intended. Moreover, it is critical that the transplanted cells do not become overabundant and cause cancer in the recipient. As a result, cellular therapies must go through a rigorous testing process before they can be made available to patients.